The Circos plot displays copy number aberrations present in cytogenetics
cases as a histogram around the circle, along with gene fusions displayed as
links between gene loci in the center of the plot. This plot can be used to
view the frequency of gene fusions present in the Mitelman database.
The green bars between the histogram and fusion links indicate the number of
unique fusion links contained within the specified chromosome band. The
color darkens as the number of fusion links increases. Hovering over the
fusion link will display the number of entries for each given gene
fusion.
The initial plot shows all available data in the Mitelman database. Users
can narrow their selection by choosing from the available topographies and
morphologies. Clicking the Apply button will update the plot showing
database entries matching the search criteria.
Tips for Circos plots:
Hover over the graph to see more information. The bar plots will display
detailed counts and chromosome bands for imbalances. The fusion links
will show the same information for fusions, in addition to the names of
the genes involved.
The green bars between the histogram and fusion links indicate the
number of fusions contained within the specified chromosome band. The
color darkens as the number of fusion links increases.
Details of the fusion genes can also be seen as a table in Gene Fusions.
For details, see Gene Fusions.
The abnormalities of the chromosomes and their genomic coordinates have been calculated by CytoConverter (Build: GRCh38)
No relevant gain or loss has been found for the selected criteria.
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Individual charts display the copy number details for each chromosome. Users
can select from the given search criteria to view the frequency of
chromosomal imbalances present in the Mitelman database for the selection.
The Histogram section provides bar charts displaying gain/loss counts
in each chromosome band, while Ideogram shows the same data on a
chromosome representation. Values used in the charts can be viewed in the
Data tab.
Tips for Copy Number plots:
Hover over each graph or ideogram to see detailed counts for the given chromosome band.
Expand the Show Display Options section to modify how the chart displays.
The abnormalities of the chromosomes and their genomic coordinates have been calculated by CytoConverter (Build: GRCh38)
No relevant gain or loss has been found for the selected criteria.
Oops! Something went wrong...
The Gene Fusions searcher allows for you to view the
morphology and
topography distributions for specific genes or gene fusions. Users can
search using individual genes or "gene1::gene2" fusion pairs and/or
cytogenetic abnormalities and breakpoints. The results
are displayed in pie charts with a table showing the data used in the
charts.